Sildenafil Citrate
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ọja Tags
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Orukọ Kemikali:
5- (2-ethoxy-5- ((4-methylpiperazin-1-yl) sulfonyl) phenyl) -1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo [4,3-d] pyrimidin- 7-ọkan 2-hydroxypropane-1,2,3-tricarboxylate
KỌỌDỌ SMILES:
"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(CC(=O)O)(C(=O)O"
Koodu InChi:
InChi=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-) 18 (16)32-6-2)33 (30,31)28-12-10-26 (3)11-13-28;7-3 (8)1-6(13,5(11)12). 2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)( H,9,10)(H,11,12)
Bọtini InChi:
DEIYFTQMQPDXOT-UHFFFAOYSA-N
Koko-ọrọ:
Sildenafil Citrate; UK 92480-10; UK-92,480-10; Revatio; VIAGRA; 171599-83-0;CAS:171599-83-0;CAS:171599-83-0
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)
Apejuwe:
Sildenafil, Citrate jẹ fọọmu citrate ti Sildenafil. Sildenafil jẹ oludena ti o yan ti PDE5 (iru 5 cGMP phosphodiesterase) eyiti o mu ki hydrolysis ti 3',5'-cyclic guanosine monophosphate (cGMP). Gẹgẹbi oludena PDE5, Sildenafil ti royin lati mu neuro-, synapto- ati angiogenesis pọ si ni awọn awoṣe eku ti ikọlu ati pe a tun royin pe o jẹ vasodilator kekere. Sildenafil tun ti han lati ṣe idiwọ idasile ọgbẹ inu ifun kekere ti indomethacin nipasẹ ọna NO / cGMP-ti o gbẹkẹle.
afojusun: PDE5