SB-204990

Orukọ Kemikali:

trans-5- [6- (2,4-Dichlorophenyl) hexyl] tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

KỌỌDỌ SMILES:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Koodu InChi:

InChi=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1) 1-16 (21)22)17 (23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Bọtini InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Koko-ọrọ:

SB-204990, SB 204990, SB204990

Solubility: 

Ibi ipamọ: 

Apejuwe:

SB-204990 jẹ prodrug ti agbara ATP citrate-lyase inhibitor SB-201076. SB-204990, nigba ti a nṣakoso ni ẹnu si awọn eku, ti gba sinu kaakiri eto, awọn ifọkansi ti oogun oogun ti SB-201076 ti gba pada ninu ẹdọ. SB-204990 (25 mg/kg fun ọjọ kan) tun dinku awọn ipele idaabobo awọ pilasima (nipasẹ si 23%) ati awọn ipele triglyceride (nipasẹ to 38%) ninu aja, ni pataki idinku lipoprotein iwuwo kekere ni akawe pẹlu idaabobo awọ lipoprotein iwuwo giga. awọn ipele. SB-204990 jẹ enzymu pataki ni ṣiṣakoso ipese sobusitireti fun iṣelọpọ ọra de novo ati ibi-afẹde henensiamu ti o pọju fun ilowosi hypolipidaemic.

Àfojúsùn: