| Ologbo # | Orukọ ọja | Apejuwe |
| CPD3611 | SB-204990 | SB-204990 jẹ prodrug ti agbara ATP citrate-lyase inhibitor SB-201076. SB-204990, nigba ti a nṣakoso ni ẹnu si awọn eku, ti gba sinu kaakiri eto, awọn ifọkansi ti oogun oogun ti SB-201076 ti gba pada ninu ẹdọ. SB-204990 (25 mg/kg fun ọjọ kan) tun dinku awọn ipele idaabobo awọ pilasima (nipasẹ si 23%) ati awọn ipele triglyceride (nipasẹ to 38%) ninu aja, ni pataki idinku lipoprotein iwuwo kekere ni akawe pẹlu idaabobo awọ lipoprotein iwuwo giga. awọn ipele. SB-204990 jẹ enzymu pataki ni ṣiṣakoso ipese sobusitireti fun iṣelọpọ ọra de novo ati ibi-afẹde henensiamu ti o pọju fun ilowosi hypolipidaemic. |
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