Resmetirom

Orukọ Kemikali:

Resmetirom

KỌỌDỌ SMILES:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

Koodu InChi:

InChi=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(4-11) 14)19)25-17 (28)21-16 (27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27, 28)

Bọtini InChi:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

Koko-ọrọ:

MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom

Solubility:Tiotuka ni DMSO, kii ṣe ninu omi

Ibi ipamọ:0 - 4 C fun igba kukuru (awọn ọjọ si awọn ọsẹ), tabi -20 C fun igba pipẹ (awọn oṣu)

Apejuwe:

Resmetirom, ti a tun mọ ni MGL-3196, jẹ agbara ti o lagbara ati yiyan homonu tairodu olugba β agonist ni awọn idanwo ile-iwosan fun itọju dyslipidemia. Awọn ipa anfani ti homonu tairodu (TH) lori awọn ipele lipid jẹ nipataki nitori iṣe rẹ ni olugba homonu tairodu β (THR-β) ninu ẹdọ, lakoko ti awọn ipa buburu, pẹlu awọn ipa inu ọkan, ti wa ni agbedemeji nipasẹ awọn olugba homonu tairodu α (THR). -a).

Àfojúsùn: THR-β