OTS964

Orukọ Kemikali:

(R) -9- (4- (1- (dimethylamino) propan-2-yl) phenyl) -8-hydroxy-6-methylthieno [2,3-c] quinolin-4 (5H) -ọkan

KỌỌDỌ SMILES:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3=C(O)C=C2C)C4=C1SC = C4

Koodu InChi:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22 (17)23 (27)24-21 (13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

Bọtini InChi:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Koko-ọrọ:

OTS 964, OTS-964, OTS964, 1338545-07-5

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

OTS964 jẹ inhibitor ti lymphokine-ṣiṣẹ apaniyan T cell-orisun protein kinase (TOPK; IC50 = 28 nM). O ṣe pataki awọn bulọọki cytokinesis, ti o yori si apoptosis, ni ọpọlọpọ awọn sẹẹli alakan. OTS964 nfa apoptosis ti awọn sẹẹli akàn ẹdọfóró eniyan ni awọn xenografts Asin.

Àfojúsùn: TOPK