GDC-0326

Orukọ Kemikali:

(S) -2-((2- (1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo [f] imidazo [1,2-d] [1,4] ]oxazepin-9-yl) oxy) propanamide

KỌỌDỌ SMILES:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Koodu InChi:

InChi=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20)26)4-5-14 (16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

Bọtini InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Koko-ọrọ:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

GDC-0326 jẹ oludena ti o lagbara ati yiyan ti α-Isoform of Phosphoinotide 3-Kinase (pi3Kalpha inhibitor). GDC-0326 ṣe aṣeyọri ipele giga pupọ ti yiyan lori awọn kinases miiran. GDC-0326 ni pilasima CL kekere ninu eniyan. Laarin idile PI3 kinase, awọn isoforms kilasi I PI3K mẹrin wa (α, β, δ, ati γ). Ninu awọn isoforms wọnyi, PI3KA jẹ eyiti o wọpọ julọ pẹlu awọn aarun.

Àfojúsùn: PI3K