Luxdegalutamide; ARV-766

Orukọ Kemikali:

4- (4- (1- (4- ((1r, 3r)) -3- (4-cyano-3-methoxyphenoxy) -2,2,4,4-tetramethylcyclobutyl) carbamoyl) phenyl) piperidin-4- yl) methyl) piperazin-1-yl)-N-((S) -2,6-dioxopiperidin-3-yl)-2-fluorobenzamide

KỌỌDỌ SMILES:

CC1(C)[C@H](NC(C2=CC=C(N3CCC(CN4CCN(C5=CC(F))) CC6=O)C=C5)CC4)CC3)C=C2=O)C(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

Koodu InChi:

InChi=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50- 39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32- 11-13-34 (35 (46)24-32)40 (56)48-36-14-15-38 (54)49-41 (36)57/h6-13,24-25,28,36, 42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0/s1

Bọtini InChi:

RDPPBRKNBBXPNZ-FMPIRMQTSA-N

Koko-ọrọ:

2750830-09-0;CAS:2750830-09-0;CAS:2750830-09-0；ARV766; ARV 766; ARV-766; GTPL12624; luxdegalutamide

Solubility: 

Ibi ipamọ:Gbẹ, dudu ati ni 0 - 4 C fun igba kukuru (ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (osu si ọdun).

Apejuwe:

Luxdegalutamide (ARV-766) jẹ amuaradagba hydrolysis ti o munadoko ti ẹnu si chimeric (PROTAC) ti o fojusi olugba androgen (AR), eyiti o le dinku awọn ẹda ti o ni ibatan AR resistance.

afojusun: AR