IACS-010759

Orukọ Kemikali:

5- (5-methyl-1- (3- (4- (methylsulfonyl)) piperidin-1-yl) benzyl) -1H-1,2,4-triazol-3-yl) -3- (4- (trifluoromethoxy) phenyl) -1,2,4-oxadiazole

KỌỌDỌ SMILES:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

Koodu InChi:

InChi=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34 (16) 15-17-4-3-5-19 (14-17)33-12-10-21 (11-13-33)39 (2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3

Bọtini InChi:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Koko-ọrọ:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

IACS-010759 tabi IACS-10759 jẹ alagbara ati yiyan Oxidative Phosphorylation Inhibitor (IC50)<10 nM) pẹlu iṣẹ ṣiṣe antineoplastic ti o pọju. IACS-010759 sopọ mọ ati ṣe idiwọ eka I ti pq irinna elekitironi (NADH ubiquinone oxidoreductase), nitorinaa yiyan awọn sẹẹli tumo ti awọn ounjẹ, ati agbara, ati idilọwọ iṣelọpọ nucleotide ati amino acid, eyiti o fa autophagy, fa iku sẹẹli tumo ati ṣe idiwọ sẹẹli afikun. Mitochondrial complex I, eyiti o jẹ hyperactivated ninu awọn sẹẹli alakan lati pade awọn ibeere ti o pọ si fun agbara, ṣe ipa pataki ninu igbega ti ilọsiwaju sẹẹli alakan.

afojusun: OXPHOS