Etoricoxib

Orukọ Kemikali:

5-Chloro-6'-methyl-3-[4- (methylsulfonyl) phenyl] -2,3'-bipyridine

KỌỌDỌ SMILES:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Koodu InChi:

InChi=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-) 13)24 (2,22)23 / h3-11H,1-2H3

Bọtini InChi:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Koko-ọrọ:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

Etoricoxib jẹ oogun sintetiki, oogun egboogi-iredodo ti kii sitẹriọdu (NSAID) pẹlu antipyretic, analgesic, ati awọn ohun-ini antineoplastic ti o pọju. Etoricoxib ni pato sopọ si ati ki o dẹkun enzymu cyclooxygenase-2 (COX-2), Abajade ni idinamọ ti iyipada ti arachidonic acid sinu prostaglandins. Idinamọ ti COX-2 le fa apoptosis ati ki o dẹkun ilọsiwaju sẹẹli tumo ati angiogenesis.

Àkọlé: COX-2