BI-2852

Orukọ Kemikali:

(S) -5-hydroxy-3- (2- (((1-- (1-methyl-1H-imidazole-4-yl)methyl) -1H-indol-6-yl)methyl) amino) methyl) -1H-indol-3-yl) isoindolin-1-ọkan

KỌỌDỌ SMILES:

OC(C=C1)=CC([C@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Koodu InChi:

InChi=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29 (24-4-2-3-5-26 (24)34-27)30-25-13-22 (38)8-9-23 (25)31 (39)35-30/h2- 13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

Bọtini InChi:

JYEQLXOWWLNVDX-PMERELPUSA-N

Koko:

Solubility: 

Ibi ipamọ: 

Apejuwe:

BI-2852 jẹ onidalẹkun KRAS ti o lagbara ti o sopọ pẹlu isunmọ nanomolar si apo kan, nitorinaa a rii pe o jẹ “aiṣedeede,” laarin yipada I ati II lori RAS. BI-2852 jẹ iyatọ ti iṣelọpọ si awọn inhibitors covalent KRASG12C nitori pe o sopọ mọ apo ti o yatọ ti o wa ninu mejeeji awọn ọna ṣiṣe ati aiṣiṣẹ ti KRAS. BI-2852 awọn bulọọki GEF, GAP, ati awọn ibaraenisepo ipa pẹlu KRAS, ti o yori si idinamọ ti ifihan agbara isalẹ ati ipa antiproliferative ninu awọn sẹẹli mutant KRAS.

afojusun: KRAS