TAS-120
Iinkcukacha zeMveliso
Iithegi zeMveliso
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Igama leMchiza:
1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl) ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl] -1-pyrrolidinyl] -2-propen-1-enye
Ikhowudi yoncumo:
C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O
Ikhowudi ye-InChi:
InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2 ,23,24,25)/t15-/m0/s1
Isitshixo se-InChi:
KEIPNCCJPRMIAX-HNNXBMFYSA-N
Igama elingundoqo:
TAS-120
Ukunyibilika:
Ugcino:
Inkcazo:
I-TAS-120 yi-oral bioavailable inhibitor ye-fibroblast growth factor receptor (FGFR) enomsebenzi onokuthi ube ne-antineoplastic. I-FGFR inhibitor TAS-120 ibophelela ngokukhethayo kwaye ingaguqukiyo kwaye inqanda i-FGFR, enokuthi ibangele ukuvinjelwa kokubini kwe-FGFR-mediated signal transduction pathway kunye ne-tumor cell proliferation, kunye nokwandisa ukufa kweeseli kwi-FGFR-overexpressing cell tumor cells. I-FGFR yi-receptor tyrosine kinase eyimfuneko kwi-tumor cell proliferation, ukwahlula kunye nokuphila kunye nokubonakaliswa kwayo kulawulwa kwiintlobo ezininzi zeeseli zethumba.
Ithagethi: FGFR
