Omarigliptin

Igama leMchiza:

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H -pyran-3-amine

Ikhowudi yoncumo:

N[C@@H]1[C@@H](C2=CC(F)=CC=C2F)OC[C@H](N3CC4=NN(S(=O)(C)=O)C= C4C3)C1

Ikhowudi ye-InChi:

InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12) 13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17- /m1/s1

Isitshixo se-InChi:

MKMPWKUAHLTIBJ-ISTRZQFTSA-N

Igama elingundoqo:

Omarigliptin,MK-3102,MK3102,Marizev,1226781-44-7

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-Omarigliptin, eyaziwa ngokuba yi-MK-3102, inamandla kwaye ithatha ixesha elide i-DPP-4 inhibitor yonyango lweveki ye-2 yeswekile. I-MK-3102 (omarigliptin), ichongiwe njenge-dipeptidyl peptidase 4 (DPP-4) inhibitor enamandla kwaye ekhethiweyo eneprofayili ye-pharmacokinetic egqwesileyo evumelekileyo kwidosi yomntu kanye ngeveki kwaye ikhethwe njengomgqatswa wophuhliso lwezonyango. I-Omarigliptin okwangoku ikwisigaba sesi-3 sophuhliso lwezonyango.

Ithagethi: DPP-4