I-Trelagliptin

Igama leMchiza:

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate

Ikhowudi yoncumo:

N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

Ikhowudi ye-InChi:

InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)1 0-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1 /s1

Isitshixo se-InChi:

IWYJYHUNXVAVAA-OAHLLOKOSA-N

Igama elingundoqo:

Trelagliptin, Trelagliptin succinate, SYR-472, Zafatek, 865759-25-7, 1029877-94-8

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).

Inkcazo:

I-Trelagliptin, ekwaziwa njenge-SYR-472, sisithinteli se-dipeptidyl peptidase-4 (DPP-4) esisebenza ixesha elide esiphuhliswa yi-Takeda kunyango lwe-2 seswekile (T2D). Kanye ngeveki unyango lwe-SYR-472 luvelise ukuphuculwa kweklinikhi kunye nezibalo ezibalulekileyo kulawulo lwe-glycemic kwizigulane ezine-2 yeswekile. Yayinyanyezelwe kakuhle kwaye inokuba lukhetho olutsha lonyango kwizigulana ezinesi sifo. I-Trelagliptin (i-Zafatek (®)) yamkelwa eJapan kunyango lwe-2 yeswekile mellitus (T2DM).

Ithagethi: DPP-4