Ertugliflozin

Igama leMchiza:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 ,4-triol

Ikhowudi yoncumo:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(O3)(CO4)CO)O)O)O)Cl "

Ikhowudi ye-InChi:

"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27) )18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18 -,19-,20+,21-,22-/m0/s1 "

Isitshixo se-InChi:

"MCIACXAZCBVDEE-CUUWFGFTSA-N"

Igama elingundoqo:

Ertugliflozin, PF 04971729,MK-8835,1210344-57-2

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).

Inkcazo:

I-Ertugliflozin, ekwabizwa ngokuba yi-PF-04971729, inamandla kwaye ikhetha inhibitor ye-sodium exhomekeke kwi-glucose cotransporter 2 kunye nomgqatswa weklinikhi kunyango lwe-2 yesifo sikashukela. Uphononongo lweklinikhi lubonise ukuba i-Ertugliflozin (i-1-25 mg / ngosuku) iphucule ulawulo lwe-glycemic, ubunzima bomzimba kunye noxinzelelo lwegazi kwizigulane ezine-T2DM ezilawulwa ngokufanelekileyo kwi-metformin, kwaye zanyamezelwa kakuhle.

Ithagethi: SGLT-2