I-BLU-667

Igama leMchiza:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

Ikhowudi yoncumo:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

Ikhowudi ye-InChi:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5 -7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32, 38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

Isitshixo se-InChi:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Igama elingundoqo:

I-BLU-667; BLU 667; I-BLU667

Ukunyibilika:I-DMSO

Ugcino: 

Inkcazo:

I-BLU-667 yi-inhibitor enamandla kwaye ekhethiweyo yokuguqulwa kwe-RET, i-fusions, kunye ne-predictive resistant mutants. I-RET fusions ngabaqhubi abaphambili bee-cancer ezininzi, kubandakanywa nomhlaza wemiphunga kunye ne-thyroid, kwaye uphando lwethu lucebisa ukuba i-RET nayo idlala indima ephambili kwezinye i-colon kunye ne-cancer yamabele. Ngokujolisa ngaxeshanye kumqhubi ophambili kunye noqikelelo lweziguquko ezixhathisayo ezinikezela iiseli zomhlaza ukuba zingakhathali kunyango ngamachiza avunyiweyo ngoku,

Ekujoliswe kuko: RET