I-BAY-299
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3( 2H)-dione
Ikhowudi yoncumo:
OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O
Ikhowudi ye-InChi:
InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8- 4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6, 11H2,1-3H3
Isitshixo se-InChi:
OFWWWWUCDUISA-UHFFFAOYSA-N
Igama elingundoqo:
BAY-299, BAY 299, BAY299, 2080306-23-4
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-BAY-299 yi-inhibitor enamandla kwaye ekhethiweyo ye-bromodomain kunye ne-PHD ene-finger-containing (BRPF) iprotheni yentsapho BRD1 (IC50 = 6 nM), eyaziwa ngokuba yi-BRPF2, kunye ne-bromodomain yesibini ye-transcription initiation factor TFIID subunits 1 (TAF1; IC50) = 13 nM).1 IBAY-299 yi>30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 kwaye i>300-fold selective over BRD4.
Ithagethi: BRPF