BI-3406
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 0.5g | Ikhona evenkileni | 850 |
| 1g | Ikhona evenkileni | 1450 |
| 5g | Ikhona evenkileni | 6200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amine
Ikhowudi yoncumo:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2
Ikhowudi ye-InChi:
InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11-17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29,30)/t12-,17+/m1/s1
Isitshixo se-InChi:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Igama elingundoqo:
BI-3406; BI 3406; BI3406
Ukunyibilika:
Ugcino:
Inkcazo:
I-BI-3406 inamandla & iKhetha i-SOS1 :: i-KRAS Inhibitor (IC50=5 nM), evula indlela eNtsha yokuNyanga i-KRAS-Driven Tumours. I-BI 3406 ibophelela ngokukhethayo kwi-SOS1 kwaye ivalela unxibelelwano ne-KRAS, kungakhathaliseki utshintsho lwe-KRAS. I-BI 3406 ibangela i-RAS GTP kunye nokunciphisa i-perK kwaye inqanda ukukhula kweeseli ze-KRAS imigca yeeseli ezitshintshileyo, ephethe uninzi lweenguqu eziqhelekileyo ze-KRAS (okt G12D, G12V, G13D kunye nezinye). I-BI 3406, xa ilawulwa ngomlomo kwi-tumor ethwele iimpuku, ibangela umthamo oxhomekeke kwi-tumor effect static enokuguqulwa ibe yi-regressions xa idibaniswe ne-MEK1 inhibition.
Ithagethi: SOS1
