| CPD10000 | BI-3406 | I-BI-3406 inamandla & iKhetha i-SOS1 :: i-KRAS Inhibitor (IC50=5 nM), evula indlela eNtsha yokuNyanga i-KRAS-Driven Tumours. I-BI 3406 ibophelela ngokukhethayo kwi-SOS1 kwaye ivalela unxibelelwano ne-KRAS, kungakhathaliseki utshintsho lwe-KRAS. I-BI 3406 ibangela i-RAS GTP kunye nokunciphisa i-perK kwaye inqanda ukukhula kweeseli ze-KRAS imigca yeeseli ezitshintshileyo, ephethe uninzi lweenguqu eziqhelekileyo ze-KRAS (okt G12D, G12V, G13D kunye nezinye). I-BI 3406, xa ilawulwa ngomlomo kwi-tumor ethwele iimpuku, ibangela umthamo oxhomekeke kwi-tumor effect static enokuguqulwa ibe yi-regressions xa idibaniswe ne-MEK1 inhibition. |
