SOS1

CAT #	Igama lemveliso	Inkcazo
CPD10000	BI-3406	I-BI-3406 inamandla & iKhetha i-SOS1 :: i-KRAS Inhibitor (IC50=5 nM), evula indlela eNtsha yokuNyanga i-KRAS-Driven Tumours. I-BI 3406 ibophelela ngokukhethayo kwi-SOS1 kwaye ivalela unxibelelwano ne-KRAS, kungakhathaliseki utshintsho lwe-KRAS. I-BI 3406 ibangela i-RAS GTP kunye nokunciphisa i-perK kwaye inqanda ukukhula kweeseli ze-KRAS imigca yeeseli ezitshintshileyo, ephethe uninzi lweenguqu eziqhelekileyo ze-KRAS (okt G12D, G12V, G13D kunye nezinye). I-BI 3406, xa ilawulwa ngomlomo kwi-tumor ethwele iimpuku, ibangela umthamo oxhomekeke kwi-tumor effect static enokuguqulwa ibe yi-regressions xa idibaniswe ne-MEK1 inhibition.
CPD2807	I-BAY-293	I-BAY-293 yi-SOS1 inhibitor enamandla evimba ukusebenza kwe-RAS ngokuphazamiseka kwe-RAS-SOS1 ukusebenzisana. I-BAY-293) inqanda ukusebenzisana kwe-KRAS-SOS1 kunye ne-IC50 ye-21 nM kwaye luphando lweekhemikhali oluxabisekileyo kuphando lwexesha elizayo.