BMS-986165

Igama leMchiza:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 -carboxamide

Ikhowudi yoncumo:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

Ikhowudi ye-InChi:

InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23) ,24,25,29)/i1D3

Isitshixo se-InChi:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Igama elingundoqo:

1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9;BMS-986165; I-BMS 986165; I-BMS986165; Deucravacitinib

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

Inkcazo:

I-BMS-986165 yi-Highly Potent and Selective Allosteric Inhibitor ye-TYK2. I-BMS-986165 Iibhloko ze-Il-12, i-IL-23 kunye nohlobo lwe-Interferon Signaling kunye nokubonelela ngokuSebenza okuQinisekileyo kwiiModeli ze-Preclinical yeSifo esivuthayo seSifo. I-MS-986165 ibophelela ngokunamandla kwi-Tyk2 pseudokinase domain (Ki = 0.02 nM), kwaye ikhetha kakhulu kwiphaneli ye-265 kinases kunye ne-pseudokinases. I-compound inhibited IL-23-, IL-12-, kunye ne-Type I-interferon-driven-driven cellular signaling and transcriptional responses (IC50 uluhlu lwe-2-14 nM).

Ithagethi: TYK2