ARS-1620
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 800 |
| 500mg | Ikhona evenkileni | 1500 |
| 1g | Ikhona evenkileni | 2000 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
Ikhowudi yoncumo:
C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl
Ikhowudi ye-InChi:
InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25- 11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2
Isitshixo se-InChi:
QIQWMIZVWVSRAS-UHFFFAOYSA-N
Igama elingundoqo:
ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-ARS-1620 yiprodrug eyenzelwe ukusuka kwi-ARS-853, eyona nto inamandla kwaye ikhethiweyo ye-S-IIP G12C inhibitor. I-ARS-1620 kulindeleke ukuba ibe sisicwangciso sonyango kwi-p.G12C KRAS yomhlaza oguqukayo.
Ekujoliswe kuko: KRAS (K-Ras G12C)
