NTN21277

Himiki ady:

(2S, 4R) -1 - ((S) -2- (3- (2 - ((5 - ((4 - oksy) pentil) oksi) et oksidi) propanamido) -3,3-dimetilbutanoýl) -4-gidroksi-N- (4- (4-metiltiazol-5 ýyl) benzil) pirrolidin-2-karboksid

SMILES kody:

O = C ([C @ H] 1N (C ([C @@ H] (NC (CCOCCOCCCCCOC2 = CC3 = C) ) = O) C (C) (C) C) = O) C [C @ H] (O) C1) NCC5 = CC = C (C6 = C (C) N = CS6) C = C5

InChi kody:

InChI = 1S / C47H57ClFN7O8S / c1-29-42 (65-28-53-29) 31-11-9-30 (10-12-31) 25-50-45 (59) 38-22-33 (57) 26-56 (38) 46 (60) 43 (47 (2,3) 4) 55-41 (58) 15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37 (24-39 (40) 61-5) 51-27-52-44 (34) 54-32-13-14-36 (49) 35 (48) 21-32 / h9-14,21,23-24 , 27-28,33,3 8,43,57H, 6-8,15-20,22,25-26H2,1-5H3, (H, 50,59) (H, 55,58) (H, 51,52,54) / t33- , 38 +, 43- / m1 / s1

InChi açary:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Açar söz:

Gefitinib esasly PROTAC 3; NTN21277; NTN-21277; NTN 21277

Çözüw: 

Saklama: 

Düşündiriş:

Gefitinib esasly PROTAC 3 diýlip hem atlandyrylýan NTN21277, HGF827 öýjügi (Exon 19 del) we H3255 öýjügi üçin DC50 11,7 nM we 22.3 nM bolan EGFR we EGFR mutantlarynyň zaýalanmagyna sebäp bolýan VHL işe alýan PROTAC.

Maksat: EGFR