PRT-060318; PRT318; P142–76
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 500mg | E teng thepeng e teng ka lebenkeleng | 900 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1350 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide
SMILES Khouto:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Khoutu ea InChi:
InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24)/t14-,15+/m0/s1
InChi Key:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
Keyword:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)
Tlhaloso:
PRT060318 ke inhibitor e matla le e khethollang ea spleen tyrosine kinase (Syk; IC50 = 4 nM). E khetha, e thibela 92% ea ts'ebetso ea Syk, ha li-kinase tse ling li boloka> 70% ts'ebetso, ka bongata ba 50 nM ka phanele ea Lik'hilograma tse 270. PRT060318 e thibela ho kopana ha plasma e nang le platelet e ngata ea motho (IC50 = 2.5 μM) in vitro le ho thibela thrombosis ka mokhoa oa transgenic mouse oa thrombocytopenia e bakoang ke heparin. E etsa hore ho be le nako e telele ea lymphocytic leukemia (CLL) B cell apoptosis 'me e thibela secretion ea chemokines CCL3, CCL4, le CXCL13.3 PRT060318 hape e thibela CLL B cell chemotaxis le pseudoemperipolesis.
Sepheo: Syk
