BAY 61-3606 2HCl

BAY 61-3606 2HCl
  • Lebitso:BAY 61-3606 2HCl
  • Nomoro ea lethathamo:CPDD1851
  • Nomoro ea CAS:648903-57-5
  • Boima ba Molek'hule:390.4
  • Foromo ea Lik'hemik'hale:Setšoantšo sa C20H18N6O3
  • Bakeng sa lipatlisiso tsa saense feela, eseng bakeng sa bakuli.

    Lintlha tsa Sehlahisoa

    Li-tag tsa Sehlahisoa

    Boholo ba Pakete Ho fumaneha Theko (USD)
    1g E teng thepeng e teng ka lebenkeleng 1200
    10g E teng thepeng e teng ka lebenkeleng 5000
    Boholo bo Eketsehileng Fumana Litlhaloso Fumana Litlhaloso

    Lebitso la lik'hemik'hale:

    2-[[7-(3,4-Dimethoxyphenyl) imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride

    SMILES Khouto:

    O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

    Khoutu ea InChi:

    InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) ;2*1H

    InChi Key:

    SPMFELFGGPQLN-UHFFFAOYSA-N

    Keyword:

    BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

    Sollubility:E qhibiliha ka DMSO

    Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

    Tlhaloso:

    BAY 61-3606 ke e matla (Ki = 7.5 nM) le inhibitor e khethiloeng ea Syk kinase. BAY 61-3606 ha e thibele feela degranulation (litekanyetso tsa IC50 pakeng tsa 5 le 46 nM) empa hape le lipid mediator le cytokine synthesis liseleng tsa mast. BAY 61-3606 e ne e sebetsa hantle haholo ho li-basophil tse fumanoeng ho batho ba phetseng hantle (IC50 = 10 nM) 'me e bonahala bonyane e le matla ho li-basophils tse fumanoang ho tloha ho atopic (high serum IgE) lihlooho (IC50 = 8.1 nM). B cell receptor activation le li-receptors bakeng sa karolo ea Fc ea pontšo ea IgG ka li-eosinophils le monocyte le tsona li ile tsa hatelloa ka matla ke BAY 61-3606.

    Sepheo: Syk


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