JBJ-04-125-02 R-isomer
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
Lebitso la lik'hemik'hale:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl) acetamide
SMILES Khouto:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Khoutu ea InChi:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28( 35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
InChi Key:
VHQVOTINPRYDAO-AREMUKBSSA-N
Keyword:
Sollubility:
Polokelo:
Tlhaloso:
JBJ-04-125-02 ke EGFR allosteric inhibitor e ikhethileng e nang le ts'ebetso e ka bang teng ea ho thibela mofetše. E le moemeli a le mong, e ka thibela ho ata ha lisele le EGFRL858R/T790M/C797S pontšo ea in vitro le in vivo. Motsoako oa osimertinib le JBJ-04-125-02 o fella ka keketseho ea apoptosis, thibelo e sebetsang haholoanyane ea kholo ea lisele, le ts'ebetso e eketsehileng ea in vitro le in vivo ha e bapisoa le moemeli a le mong feela.
Sepheo: EGFR
