Omarigliptin

Lebitso la lik'hemik'hale:

(2R,3S,5R) -2-(2,5-difluorophenyl) -5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H -pyran-3-amine

SMILES Khouto:

N[C@@H]1[C@@H](C2=CC(F)=CC=C2F)OC[C@H](N3CC4=NN(S(=O)(C)=O)C= C4C3)C1

Khoutu ea InChi:

InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9) -12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+ ,17-/m1/s1

InChi Key:

MKMPWKUAHLTIBJ-ISTRZQFTSA-N

Keyword:

Omarigliptin,MK-3102,MK3102,Marizev,1226781-44-7

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

Tlhaloso:

Omarigliptin, e tsejoang hape e le MK-3102, ke inhibitor e matla le e nkang nako e telele ea DPP-4 bakeng sa kalafo ea hang ka beke ea lefu la tsoekere la mofuta oa 2. MK-3102 (omarigliptin), e khethiloe e le inhibitor e matla le e khethang ea dipeptidyl peptidase 4 (DPP-4) e nang le profil e ntle ea pharmacokinetic e amohelehang bakeng sa ho noa ha motho hanngoe ka beke le ho khethoa e le mokhethoa oa nts'etsopele ea bongaka. Omarigliptin hajoale e ntse e le mohatong oa 3 oa nts'etsopele ea bongaka.

Sepheo: DPP-4