Sitagliptin

Lebitso la lik'hemik'hale:

Sitagliptin (INN; e neng e tsejoa pele e le MK-0431 mme e rekisoa ka lebitso la khoebo la Januvia) ke sethethefatsi sa molomo sa antihyperglycemic (anti-diabetic) sa sehlopha sa dipeptidyl peptidase-4 (DPP-4) inhibitor.

SMILES Khouto:

O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O.[H]O[H]

Khoutu ea InChi:

InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13(7- 26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1, 2,3,4);1H2/t9-;;/m1../s1

InChi Key:

GQPYTJVDPQTBQC-KLQYNRQASA-N

Keyword:

Sitagliptin,Sitagliptin phosphate,Januvia,Glactiv,ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

Tlhaloso:

Sitagliptin (INN; e neng e tsejoa pele e le MK-0431 mme e rekisoa ka lebitso la khoebo la Januvia) ke sethethefatsi sa molomo sa antihyperglycemic (anti-diabetic) sa sehlopha sa dipeptidyl peptidase-4 (DPP-4) inhibitor. E ile ea hlahisoa 'me e rekisoa ke Merck & Co. Sethethefatsi sena se thibelang li-enzyme se sebelisoa e le mong kapa se kopane le li-antihyperglycemic agents tse ling (tse kang metformin kapa thiazolidinedione) bakeng sa phekolo ea lefu la tsoekere la mofuta oa 2. Molemo oa meriana ena ke litla-morao tsa eona tse tlase (mohlala, hypoglycemia e fokolang, boima ba 'mele bo fokolang) taolong ea boleng ba tsoekere ea mali. Exenatide (Byetta) e boetse e sebetsa ka phello ea eona tsamaisong ea incretin.

Sepheo: DPP-4