Trelagliptin

Lebitso la lik'hemik'hale:

(R) -2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate

SMILES Khouto:

N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

Khoutu ea InChi:

InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14( 19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1

InChi Key:

IWYJYHUNXVAVAA-OAHLLOKOSA-N

Keyword:

Trelagliptin, Trelagliptin succinate, SYR-472, Zafatek, 865759-25-7, 1029877-94-8

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

Tlhaloso:

Trelagliptin, eo hape e tsejoang e le SYR-472, ke inhibitor ea dipeptidyl peptidase-4 (DPP-4) e sebetsang nako e telele e ntseng e etsoa ke Takeda bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2 (T2D). Phekolo ea hang ka beke ea SYR-472 e hlahisitse lintlafatso tsa bohlokoa tsa bongaka le lipalo-palo taolong ea glycemic ho bakuli ba nang le lefu la tsoekere la mofuta oa 2. E ne e mamelloa hantle mme e kanna ea ba khetho e ncha ea kalafo ho bakuli ba nang le lefu lena. Trelagliptin (Zafatek(®)) e amohetsoe Japane bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2 mellitus (T2DM).

Sepheo: DPP-4