Ertugliflozin

Lebitso la lik'hemik'hale:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 , 4-triol

SMILES Khouto:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(O3)(CO4)CO)O)O)O)Cl"

Khoutu ea InChi:

"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27) )18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18 -,19-,20+,21-,22-/m0/s1 "

InChi Key:

"MCIACXAZCBVDEE-CUUWFGFTSA-N"

Keyword:

Ertugliflozin, PF 04971729,MK-8835,1210344-57-2

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

Tlhaloso:

Ertugliflozin, eo hape e tsejoang e le PF-04971729, ke inhibitor e matla le e khethang ea sodium e itšetlehileng ka glucose cotransporter 2 le moemeli oa bongaka bakeng sa kalafo ea mofuta oa 2 lefu la tsoekere. Boithuto ba tleliniki bo bonts'itse hore Ertugliflozin (1-25 mg / letsatsi) e ntlafalitse taolo ea glycemic, boima ba 'mele le khatello ea mali ho bakuli ba nang le T2DM e laoloang hanyane ka metformin,' me e mamelloa hantle.

Sepheo: SGLT-2