AZD8186

Lebitso la lik'hemik'hale:

(R) -8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

SMILES Khouto:

O=C(N(C)C)C1=CC([C@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Khoutu ea InChi:

InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1

InChi Key:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Keyword:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

Tlhaloso:

AZD8186 ke inhibitor ea beta isoform ea phosphoinositide-3 kinase (PI3K), e nang le ts'ebetso e ka bang teng ea antineoplastic. Ka mor'a tsamaiso, PI3Kbeta inhibitor AZD8186 e thibela ka mokhoa o ikhethileng mosebetsi oa PI3Kbeta tseleng ea pontšo ea PI3K/Akt/mTOR, e ka fellang ka ho fokotseha ha ho ata ha lisele tsa tumor. E boetse e baka lefu la lisele ho lisele tsa mofetše tse hlahisang PI3K. Ka ho shebana le beta ea sehlopha sa I PI3K ka ho khetheha, moemeli enoa a kanna a sebetsa hantle mme a se chefo ho feta pan PI3K inhibitors. Letšoao la PI3K-mediated hangata le felloa ke matla ka har'a lisele tsa mofetše 'me le kenya letsoho ho eketseheng ha lisele tsa tumor, ho phela, le ho hanyetsa hlahala ho mefuta e fapaneng ea li-antineoplastic agents. AZD8186 hajoale e tlas'a liteko tsa bongaka tsa Phase I.

Sepheo: PI3K