Quizartinib; AC-010220; AC-220
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 5g | E teng thepeng e teng ka lebenkeleng | 1000 |
| 10g | E teng thepeng e teng ka lebenkeleng | 1500 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea
SMILES Khouto:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C)(C)C)=C6
Khoutu ea InChi:
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChi Key:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Keyword:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)
Tlhaloso:
Quizartinib ke inhibitor ea tyrosine kinase 3 e amanang le FMS (FLT3; Kd = 1.6 nM) 'me e bontša khetho e phahameng bakeng sa FLT3 ha e lekoa khahlanong le sehlopha sa 227 kinases e eketsehileng. E thibela ho ata ha leukemia cell line ea motho MV4-11, e nang le phetoho ea homozygous FLT3-ITD, e nang le boleng ba IC50 ba 0.56 nM.1 Ho 1 mg/kg/letsatsi, quizartinib e bontšitsoe ho atolosa ho phela ho toeba. mohlala oa FLT3-ITD acute myeloid leukemia le ho felisa lihlahala ka mokhoa oa FLT3 o itšetlehileng ka mouse xenograft ka 10 mg / kg.
Sepheo: FLT3
