TH-302; Evofosfamide

TH-302; Evofosfamide
  • Magaca:TH-302; Evofosfamide
  • Lambarka buugga:CPDB1510
  • Lambarka CAS:918633-87-1
  • Miisaanka Molecular:449.04
  • Foomka Kiimikada:C9H16Br2N5O4P
  • Cilmi baaris cilmiyeed oo keliya, ma ahan bukaanka.

    Faahfaahinta Alaabta

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    Cabbirka Xidhmada Helitaanka Qiimaha (USD)
    100mg In Stock 360
    1g In Stock 1000
    Cabiro badan Hel Xigasho Hel Xigasho

    Magaca Kiimikada:

    N, N'-Bis (2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl) methyl ester

    Koodhka dhoola cadeynta:

    O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O) N1C

    Koodhka InChi:

    InChi=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

    Furaha InChi:

    UGJWRPJDTDGERK-UHFFFAOYSA-N

    Ereyga muhiimka ah:

    TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

    Xalka:Ku milmay DMSO

    Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

    Sharaxaad:

    Evofosfamide, oo sidoo kale loo yaqaan TH-302, waa dawada hypoxia-firfircoon oo ka kooban 2-nitroimidazole phosphoramidate conjugate oo leh firfircoonida antineoplastic ee suurtagalka ah. 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 u dhaqmo sida kicin hypoxic, sii daayo DNA-alkylating dibromo isophosphoramide mustard moiety gudaha gobollada hypoxic ee burooyinka. Unugyada Normoxic ayaa laga yaabaa in lagu badbaadsho sababtoo ah shaqada hypoxia-gaar ah ee wakiilkan, taas oo suurtogal ah in la yareeyo sunta nidaamka. Hubi tijaabooyin caafimaad oo firfircoon ama tijaabooyin caafimaad oo xidhan adoo isticmaalaya wakiilkan. (NCI).

    Hadafka: Wakiilka Alkylating DNA


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