TH-302; Evofosfamide
Faahfaahinta Alaabta
Tags Product
Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
100mg | In Stock | 360 |
1g | In Stock | 1000 |
Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
N, N'-Bis (2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl) methyl ester
Koodhka dhoola cadeynta:
O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O) N1C
Koodhka InChi:
InChi=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)
Furaha InChi:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Ereyga muhiimka ah:
TH-302, TH302, TH 302, Evofosfamide, 918633-87-1
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)
Sharaxaad:
Evofosfamide, oo sidoo kale loo yaqaan TH-302, waa dawada hypoxia-firfircoon oo ka kooban 2-nitroimidazole phosphoramidate conjugate oo leh firfircoonida antineoplastic ee suurtagalka ah. 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 u dhaqmo sida kicin hypoxic, sii daayo DNA-alkylating dibromo isophosphoramide mustard moiety gudaha gobollada hypoxic ee burooyinka. Unugyada Normoxic ayaa laga yaabaa in lagu badbaadsho sababtoo ah shaqada hypoxia-gaar ah ee wakiilkan, taas oo suurtogal ah in la yareeyo sunta nidaamka. Hubi tijaabooyin caafimaad oo firfircoon ama tijaabooyin caafimaad oo xidhan adoo isticmaalaya wakiilkan. (NCI).
Hadafka: Wakiilka Alkylating DNA