AZD7507

Magaca Kiimikada:

4- (2-fluoro-4-methylanilino) -6-[4- (2-hydroxyethyl) piperazin-1-yl] -7-methoxycinnoline-3-carboxamide

Koodhka dhoola cadeynta:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Koodhka InChi:

InChi=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31)20 (33-2)13-18 (15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2) ,25,32)(H,26,27)

Furaha InChi:

CPDGCAFPYOTGO-UHFFFAOYSA-N

Ereyga muhiimka ah:

AZD7507; AZD-7507; Tusmada ugu hooseysa ee 7507

Xalka:DMSO

Kaydinta: 

Sharaxaad:

AZD7507 waa awood iyo xulashada CSF-1R inhibitor (32 nM dhaqdhaqaaqa unugyada), AZD7507 waxaa loo tixgeliyaa xarun rajo leh maadaama ay sii haysato awoodda la rabo iyo guryaha farmashiyaha afka ee AZ683. Waxaa intaa dheer, daraasadda telemetry ee eeyaha la siiyay hal dose oo afka ah, ma jirin sunta wadnaha iyo xididdada, kor u kaca troponin ee la xidhiidha daaweynta, iyo wax isbeddel ah oo ku yimid ECG.

Hadafka: CSF-1R