BI-847325

Magaca Kiimikada:

(Z) -3- (3-((((((((((4- ((dimethylamino)))) methyl)))

Koodhka dhoola cadeynta:

O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4

Koodhka InChi:

InChi=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-) 6-5-7-9-2 2)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30 ,34)(H,32,35)/b28-27-

Furaha InChi:

FLBNLJLONKAPLR-DQSJHHFOSA-N

Ereyga muhiimka ah:

BI-847325, BI847325, BI 847325, 1207293-36-4

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

BI-847325 waa dual la doortay MEK/Aurora kinase inhibitor oo leh IC50 qiimaha 3, 25, 15, 25, iyo 4 nM ee X. laevis Aurora B, aadanaha Aurora A iyo Aurora C, iyo aadanaha MEK1 iyo MEK2, siday u kala horreeyaan. Waxay joojin kartaa korriinka iyo badbaadada labadaba daawaynta-naive-ka iyo dawada u adkaysata xariiqyada unugyada melanoma, hoos u dhigista muujinta MEK iyo Mcl-1 iyadoo kordhinaysa muujinta borotiinka pro-apoptotic Bim. At 70 mg/kg, BI-847325 waxay keentaa apoptosis ee daawaynta-naive iyo daawada u adkaysata xenografted melanoma in vivo.

Bartilmaameedka: MEK/Aurora