Derazantinib; ARQ-087

Magaca Kiimikada:

(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl] phenyl]-Benzo[h] quinazolin-2-amine

Koodhka dhoola cadeynta:

COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1

Koodhka InChi:

InChi=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24- 10-4-5-12-2 7 (24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H ,32,33,34)/t26-/m1/s1

Furaha InChi:

KPJDVVCDVBFRMU-AREMUKBSSA-N

Ereyga muhiimka ah:

Derazantinib, ARQ-087, ARQ087, ARQ 087, 1234356-69-4

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

Derazantinib, oo sidoo kale loo yaqaan ARQ-087, waa xannibaadaha afka laga heli karo ee soo-dhoweeyaha koritaanka fibroblast (FGFR) oo leh firfircoonida antineoplastic ee suurtagalka ah. FGFR inhibitor ARQ 087 waxay ku xidhaa oo si xoog leh u joojisaa dhaqdhaqaaqa FGFR-hoosaadka 1, 2 iyo 3. Tani waxay keeni kartaa in la joojiyo dariiqyada gudbinta calaamadaha FGFR-dhexdhexaadin, kororka unugyada burooyinka, buro angiogenesis iyo dhimashada unugyada burooyinka ee FGFR-aad u muujiya unugyada burooyinka . FGFR, reseptor tyrosine kinase, ayaa lagu hagaajiyay noocyo badan oo unugyo burooyin ah waxayna door muhiim ah ka ciyaaraan kororka unugyada burooyinka, kala duwanaanta, angiogenesis iyo badbaadada.

Ujeedka: FGFR