SB-204990

Chemical Name:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

SMILES Kodhi:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

InChi Code:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21) 22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

InChi Key:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Keyword:

SB-204990, SB 204990, SB204990

Solubility: 

Kuchengeta: 

Tsanangudzo:

SB-204990 ndiyo prodrug yeakasimba ATP citrate-lyase inhibitor SB-201076. SB-204990, painopihwa nemuromo kumakonzo, yakanyudzwa mukati me systemic kutenderera, pharmacologically yakakosha kutariswa kweSB-201076 yakadzoserwa muchiropa. SB-204990 (25 mg/kg pazuva) zvakare yakaderedza plasma cholesterol mazinga (kusvika kusvika 23%) uye triglyceride mazinga (kusvika kusvika 38%) mumbwa, zvichinyanya kuderera pasi-density lipoprotein kana ichienzaniswa nepamusoro-density lipoprotein cholesterol. mazinga. SB-204990 inzyme yakakosha mukudzora substrate kupihwa kwelipid synthesis de novo uye inogona kuita enzyme tarisiro yekupindira kwe hypolipidemic.

Chinangwa: