AZD-5069
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 500 |
| 500mg | Mudura | 800 |
| 1g | Mudura | 1200 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
SMILES Kodhi:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
InChi Code:
InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-1 0-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H ,21,22,23)/t11-,14+/m1/s1
InChi Key:
QZECRCLSIGFCIO-RISCZKNCSA-N
Keyword:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
AZD-5069 imhandu ine simba uye inosarudza CXCR2 ine mukana wekudzivisa neutrophil kutama mumhepo kune varwere vane COPD. AZD-5069 yakaratidzwa kuvharidzira kusunga kweradiolabed CXCL8 kumunhu CXCR2 ine pIC50 kukosha kwe9.1. Uyezve, AZD5069 inhibited neutrophil chemotaxis, ine pA2 inenge 9.6, uye adhesion molecule kutaura, ine pA2 ye6.9, maererano neCXCL1. AZD5069 yaive mhandu inodzokororwa zvishoma nezvishoma yeCXCR2 nemhedzisiro yenguva uye tembiricha zvinoonekwa pane pharmacology uye kusunga kinetics. AZD-5069 inogonawo kubatsira kune murwere mumamiriro ekuzvimba.
Chinangwa: CXCR2