IACS-010759

Igoa vaila'au:

5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl) -1,2,4-oxadiazole

SMILES Code:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O))(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

InChi Code:

InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31 -34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H ,10-13,15H2,1-2H3

InChi Key:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

upu autu:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

IACS-010759 poʻo le IACS-10759 o se malosi ma filifilia Oxidative Phosphorylation Inhibitor (IC50).<10 nM) fa'atasi ai ma gaioiga antineoplastic. IACS-010759 fusifusia ma faʻalavelave faʻalavelave I o le filifili felauaiga eletise (NADH ubiquinone oxidoreductase), ma faʻapena le filifilia o sela tumo o meaʻai, ma le malosi, ma faʻalavelaveina le gaosiga o le nucleotide ma le amino acid, lea e faʻaosofia ai le autophagy, mafua ai le maliu o le tumo ma faʻalavelaveina le cell. fa'ateleina. O le Mitochondrial complex I, lea e fa'agaioia i sela o le kanesa e fa'amalieina ai lo latou mana'omia tele mo le malosi, e faia se sao taua i le fa'alauteleina o le fa'ateleina o sela o le kanesa.

Sini: OXPHOS