Flibanserin

Izina ryimiti:

1- (2- (4- (3- (trifluoromethyl) phenyl) piperazin-1-yl) ethyl) -1H-benzo

Kode ya SMILES:

O = C1NC2 = CC = CC = C2N1CCN3CCN (C4 = CC = CC (C (F) (F) F) = C4) CC3

InChi Code:

InChI = 1S / C20H21F3N4O / c21-20 (22,23) 15-4-3-5-16 (14-15) 26-11-8-25 (9-12-26) 10-13-27-18- 7-2-1-6-17 (18) 24-19 (27) 28 / h1-7,14H, 8-13H2, (H, 24,28)

InChi Urufunguzo:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Ijambo ryibanze:

Flibanserin, 167933-07-5

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Flibanserin ni agonist yuzuye ya reseptor ya 5-HT1A (Ki = 1 nM) kandi, hamwe n’umubano muto, nkumuntu urwanya reseptor ya 5-HT2A (Ki = 49 nM) na antagonist cyangwa intege nke cyane agonist ya reseptor ya D4 ( Ki = 4–24 nM). Nuburyo bwinshi bwa flibanserin kubakira 5-HT1A, kandi kubwimpamvu zitazwi, flibanserin ifata reseptor 5-HT1A na 5-HT2A muri vivo hamwe nijanisha risa. Flibanserin ifite kandi ubucuti buke kuri reseptor ya 5-HT2B (Ki = 89.3 nM) hamwe na reseptor ya 5-HT2C (Ki = 88.3 nM), byombi bitwara nka antagonist ya. Flibanserin ikunda gukora 5-HT1A yakira muri cortex ibanza, ikerekana guhitamo kwakarere, kandi byagaragaye ko byongera urugero rwa dopamine na norepinephrine kandi bikagabanya urugero rwa serotonine muri cortex yimbeba, ibikorwa byari byiyemeje gukemurwa no gukora 5-HT1A reseptor. Nkibyo, flibanserin yasobanuwe nka norepinephrine-dopamine disinhibitor (NDDI). Flibanserin yemejwe muri Kanama 2015 kugira ngo avurwe n'abagore mbere yo gucura bafite ikibazo cyo guhuza ibitsina cyane (HSDD).

Intego: 5HT