IACS-010759
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 300 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl) -1,2,4-oxadiazole
SMILES Kodi:
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1
InChi kodi:
InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3
InChi Key:
HWJWNWZJUYCGKV-UHFFFAOYSA-N
Mawu ofunika:
IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
IACS-010759 kapena IACS-10759 ndi yamphamvu komanso yosankha Oxidative Phosphorylation Inhibitor (IC50).<10 nM) yokhala ndi zochita za antineoplastic. IACS-010759 imamangiriza ndikuletsa zovuta I za unyolo wa ma elekitironi (NADH ubiquinone oxidoreductase), potero amalepheretsa maselo otupa a michere, mphamvu, ndikuletsa kupanga ma nucleotide ndi amino acid, omwe amapangitsa autophagy, kumayambitsa kufa kwa cell ndikuletsa cell. kuchuluka. Mitochondrial complex I, yomwe imakhala ndi mphamvu zambiri m'maselo a khansa kuti ikwaniritse zofuna zawo zowonjezera mphamvu, imagwira ntchito yofunika kwambiri polimbikitsa kuchuluka kwa maselo a khansa.
Cholinga: OXPHOS