GDC-0326

Dzina la Chemical:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

SMILES Kodi:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

InChi kodi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

InChi Key:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Mawu ofunika:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Kusungunuka:Zosungunuka mu DMSO

Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)

Kufotokozera:

GDC-0326 ndi inhibitor yamphamvu komanso yosankha ya α-Isoform ya Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 imakwaniritsa kusankhidwa kwapamwamba kwambiri kuposa ma kinase ena. GDC-0326 ili ndi plasma yotsika CL mwa anthu. Mkati mwa banja la PI3 kinase, muli ma isoform anayi a I PI3K (α, β, δ, ndi γ). Mwa ma isoform awa, PI3Kα ndiyomwe imalumikizidwa kwambiri ndi khansa.

Cholinga: PI3K