BAY-850

Dzina la Chemical:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -(((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

SMILES Kodi:

ClC(C(C(N[C@H])(CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

InChi kodi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35( 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

InChi Key:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Mawu ofunika:

BAY-850; BAY850; PA 850

Kusungunuka:DMSO

Posungira: 

Kufotokozera:

"BAY-850 ndi kafukufuku wamankhwala a ATAD2A bromodomain omwe amachotsa acetylated H4 peptide kuchokera ku ATAD2 bromodomain yokhala ndi IC50 value ya 20 nM (HTRF). Miyezo ya MST ndi BROMOscan imasonyeza Kd ya 84.9 nM ndi 120 nM, motsatira BAY-. 850 imawonetsa kusankhidwa kwabwino pa ma bromodomain ena onse (palibe kugunda mu BROMOscan pa 10 µM) ndikuchotsa utali wonse wa ATAD2 kuchokera ku chromatin m'maselo amoyo pamlingo wa 1 µM monga momwe FRAP imatsimikizira 5 µM sizovomerezeka (http://www.thesgc.org/chemical-probes/BAY-850) "

Cholinga: kafukufuku wamankhwala wa ATAD2A bromodomain