BAY598 R-isomer

Dzina la Chemical:

(R,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl) -4,5-dihydro-1H-pyrazol- 4-yl) -N-ethyl-2-hydroxyacetamide

SMILES Kodi:

CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O

InChi kodi:

InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 ( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1

InChi Key:

OTTJIRVZJJGFTK-GOSISDBHSA-N

Mawu ofunika:

BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer

Kusungunuka:DMSO

Posungira: 

Kufotokozera:

BAY-598 R-isomer ndi R-isomer ya BAY589. BAY-598 R-isomer ikhoza kugwiritsidwa ntchito ngati cholumikizira. BAY-598 ndi kafukufuku wamphamvu, wopikisana ndi peptide wa SMYD2. BAY-598 ili ndi chemotype yapadera yokhudzana ndi kafukufuku wamakono wa SMYD2 LLY-507. BAY-598 imalepheretsa mu vitro methylation ya p53K370 yokhala ndi IC50 = 27 nM ndipo ili ndi kusankha kopitilira 100 pa histone methyltransferase ndi zolinga zina zomwe si za epigenetic. BAY-598 imalepheretsa methylation ya p53K370 m'maselo okhala ndi IC50.<1µM. (Kupitilira apa, BAY-598 ili ndi zinthu zomwe zimagwirizana ndi kuyesa kwa vivo.) Gulu lowongolera, BAY-369, lapangidwanso. BAY-369 imaletsa in vitro methylation ya p53K370 ndi IC50 >70 micromolar.

Zolinga: