AZD-5069
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 500 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
SMILES Kodi:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
InChi kodi:
InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16) 30-1 0-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H ,21,22,23)/t11-,14+/m1/s1
InChi Key:
QZECRCLSIGFCIO-RISCZKNCSA-N
Mawu ofunika:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
AZD-5069 ndi antagonist amphamvu komanso osankha a CXCR2 omwe amatha kuletsa kusamuka kwa neutrophil kupita ku airways kwa odwala omwe ali ndi COPD. AZD-5069 idawonetsedwa kuti imaletsa kumangirira kwa CXCL8 yojambulidwa ndi ma radio kwa munthu CXCR2 yokhala ndi mtengo wa pIC50 wa 9.1. Kuphatikiza apo, AZD5069 inhibited neutrophil chemotaxis, yokhala ndi pA2 pafupifupi 9.6, ndi mawu a adhesion molecule, okhala ndi pA2 ya 6.9, poyankha CXCL1. AZD5069 anali mdani wosinthika pang'onopang'ono wa CXCR2 ndi zotsatira za nthawi ndi kutentha zikuwonekera pa pharmacology ndi kinetics yomanga. AZD-5069 imathanso kukhala yothandiza kwa odwala omwe ali ndi vuto lotupa.
Cholinga: CXCR2