Ingliforib

Isem Kimiku:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)- 1H-indol-2-carboxamide

Kodiċi SMILES:

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

Kodiċi InChi:

InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13)21(30)23(3 2)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8,11-12H2,(H,26,31 )/t17-,19-,20+,21+/m0/s1

InChi Key:

GVDRRZOORHCTAN-MJUUVYJYSA-N

Keyword:

Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296

Solubilità:DMSO

Ħażna: 

Deskrizzjoni:

Ingliforib, magħruf ukoll bħala CP-368296, huwa inibitur ġdid tal-glycogen phosphorylase. Ingliforib għandu proprjetajiet anti-ipergliċemiċi u kardjoprotettivi. Ingliforib jinibixxi glycogen phosphorylase, l-enzima li tillimita r-rata fil-glycogenolysis, u b'hekk jipprevjeni r-rilaxx ta 'glucose-1 phosphate minn molekula ta' glycogen fil-fwied. Dan l-aġent jinibixxi wkoll glycogen phosphorylase fil-muskolu kardijaku u jista 'jipproteġi l-qalb minn korriment iskemiku mijokardijaku billi jippreserva l-kontenut ta' glycogen u jtejjeb l-akkoppjar glikolitiku-ossidant.

Mira: glycogen phosphorylase