Sildenafil Citrate
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Ingoa matū:
5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin- 7-kotahi 2-hydroxypropane-1,2,3-tricarboxylate
Waehere SMILES:
"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(CC(=O)O)(C(=O)O)O "
Waehere InChi:
InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12) 2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)( H,9,10)(H,11,12)
Kī InChi:
DEIYFTQMQPDXOT-UHFFFAOYSA-N
Kupumatua:
Sildenafil Citrate;UK 92480-10;UK-92,480-10; Revatio; VIAGRA;171599-83-0;CAS:171599-83-0;CAS:171599-83-0
Wairewa:Wairewa i roto i te DMSO
Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)
Whakaahuatanga:
Sildenafil, Ko te Citrate he ahua citrate o Sildenafil. Ko te Sildenafil he aukati whiriwhiri o PDE5 (momo 5 cGMP phosphodiesterase) e whakakorikori ana i te hydrolysis o te 3',5'-cyclic guanosine monophosphate (cGMP). Ka rite ki te aukati PDE5, kua korerotia a Sildenafil ki te whakarei ake i te neuro-, synapto- me te angiogenesis i roto i nga tauira kiore o te whiu me te korero ano he vasodilator ngawari. Kua whakaatuhia hoki a Sildenafil ki te aukati i te hanga o te whewhe whewhe iti na te indomethacin na roto i te tikanga NO/cGMP-whakaaro.
Whāinga: PDE5