S-600918，Sivopixant

Ingoa matū:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl]-2-methylpropanoic acid

Waehere SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Waehere InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

Kī InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Kupumatua:

2414285-40-6; CAS:2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Wairewa:Wairewa i roto i te DMSO

Rokiroki:He maroke, he pouri me te 0 - 4 C mo te wa poto (nga ra ki nga wiki) ranei -20 C mo te wa roa (marama ki nga tau)

Whakaahuatanga:

Ko te Sivopixant, e mohiotia ana ko S-600918, he kaitukino kaikawe P2X3 (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). I whakaatu a Sivopixant i te kaha analgesic kaha i roto i te ahua o te kiore i te waahanga o te kiore sciatic (tauira Seltzer) o te allodynia (ED50, 0.4 mg / kg).

Whāinga: He kaitukino kaikawe P2X3 kua tohua