Quarfloxin

Ingoa matū:

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Waehere SMILES:

FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

Waehere InChi:

InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42-29-15-21-5-2-3-6- 22(21)16-30(29)45-34-31(42)25(33(26)43)17-27(36)32(34)41-14-9-23(19-41)28- 18-37-11-12-38-28/h2-3,5-6,11-12,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H ,39,44)/t23-,24+/m1/s1

Kī InChi:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

Kupumatua:

CX 3543; CX-3543; CX 3543; Quarfloxacin

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te Quarfloxin, e mohiotia ana ko Quarfloxacin me CX-3543, he huanga fluoroquinolone me te mahi antineoplastic. Ka pakaru te Quarfloxin i te taunekeneke i waenga i te pūmua nucleolin me te hanganga DNA G-quadruplex i roto i te tauira DNA ribosomal (rDNA), he whakawhitiwhitinga tino nui mo te rRNA biogenesis e kaha ake ana i roto i nga pukupuku pukupuku; te whakararu o tenei G-quadruplex DNA: ko te taunekeneke pūmua i roto i te kotiti rRNA biogenesis ka hua pea te aukati i te whakahiato ribosome me te apoptosis pūtau puku.

Whāinga: