| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD100608 | ASK1-Aue-10 | Ko te ASK1 Inhibitor 10 he aukati koiora-a-waha mo te apoptosis tohu-whakahaere kinase 1 (ASK1). He mea whiriwhiri mo ASK1 mo ASK2 me MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, me B-RAF. Ka whakakorehia e te streptozotocin te whakanui ake i te JNK me te p38 phosphorylation i roto i nga pūtau β pancreatic INS-1 i roto i te ahua o te kukū. |
| CPD100607 | K811 | Ko te K811 he aukati ASK1-motuhake e whakaroa ana i te oranga i roto i te tauira kiore o te amyotrophic lateral sclerosis. He pai te aukati a K811 i te tipu o te pūtau i roto i nga raina pūtau me te whakapuaki ASK1 teitei me nga pūtau GC-HER2-overexpressing. Ko te maimoatanga me te K811 kua whakahekehia te rahi o nga pukupuku xenograft ma te whakaheke i nga tohu whakahiato. |
| CPD100606 | K812 | Ko te K812 he aukati ASK1-motuhake i kitea hei whakaroa i te oranga i roto i te tauira kiore o te amyotrophic lateral sclerosis. |
| CPD100605 | MSC-2032964A | Ko te MSC 2032964A he kaha me te whiriwhiri i te aukati ASK1 (IC50 = 93 nM). Ka aukatihia e te LPS te ASK1 me te p38 phosphorylation i roto i nga astrocytes kiore whakatipu me te whakakore i te neuroinflammation i roto i te tauira EAE kiore. Ko te MSC 2032964A kei te waatea-a-waha me te uru ki te roro. |
| CPD100604 | Selonsertib | Ko Selonsertib, e mohiotia ana ko GS-4997, he aukati koiora o te apoptosis tohu-whakahaere kinase 1 (ASK1), me nga mahi anti-inflammatory, antineoplastic me te anti-fibrotic. Ko te GS-4997 te whaainga me te herea ki te rohe catalytic kinase o ASK1 i roto i te whakataetae ATP, na reira ka aukati i tana phosphorylation me te whakahohe. Ko te GS-4997 te aukati i te hanga o nga cytokines inflammatory, te whakaheke-whakahaere i te whakaaturanga o nga ira e uru ana ki te fibrosis, te aukati i te apoptosis nui me te aukati i te tipu o te pūtau. |
