| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD100603 | MDK36122 | Ko te MDK36122, e mohiotia ana ko H-PGDS Inhibitor I, he Prostaglandin D Synthase (hematopoietic-type) Inhibitor. MDK36122 karekau he ingoa waehere, he CAS#1033836-12-2. Ko te 5-mati whakamutunga i whakamahia hei ingoa mo te ngawari o te whakawhitiwhiti korero. Ko te MDK36122 he aukati i te HPGDS (IC50s = 0.7 me te 32 nM i roto i nga whakamaarama me nga whakamatautau pūtau, ia) me te iti o te mahi ki te taha o nga enzymes tangata L-PGDS, mPGES, COX-1, COX-2, me 5-LOX. |
| CPD100602 | Tepoxalin | Tepoxalin, e mohiotia ana ko ORF-20485; RWJ-20485; he aukati 5-lipoxygenase pea mo te maimoatanga o te mate huango, osteoarthritis (OA). Tepoxalin he in vivo mahi aukati ki COX-1, COX-2, me te 5-LOX i roto i nga kuri i te inenga kua whakaaetia o naianei.Ka whakakorehia e te Tepoxalin te mumura me te ngoikoretanga o te microvascular na te irradiation puku i roto i nga kiore. Ka whakanui ake te Tepoxalin i te mahi o te antioxidant, pyrrolidine dithiocarbamate, ki te whakaiti i te take necrosis pukupuku alpha-induced apoptosis i roto i nga pūtau WEHI 164. |
| CPD100601 | Tenidap | Ko Tenidap, e mohiotia ana ko CP-66248, he kaiwhakahau COX/5-LOX me te kaitono tarukino anti-inflammatory cytokine-modulating i raro i te whakawhanaketanga e Pfizer hei rongoa pai mo te mate rūmātiki, engari i aukati a Pfizer i te whakawhanaketanga i muri i te whakahēnga o te whakaaetanga hokohoko. na te FDA i te tau 1996 na te paitini o te ate me te whatukuhu, i kiia ko nga metabolites o te tarukino me te waahanga thiophene. na te kino o te oxidative. |
| CPD100600 | PF-4191834 | Ko te PF-4191834 he pukapuka, he kaha me te whiriwhiri kore-redox 5-lipoxygenase inhibitor e whai hua ana ki te mumura me te mamae. Ko te PF-4191834 e whakaatu ana i te kaha pai i roto i nga whakawaehere-a-a-puutau, me te tauira kiore o te mumura whakapeka. Ko nga hua o te whakamatautau i te Enzyme e tohu ana ko te PF-4191834 he aukati 5-LOX kaha, me te IC(50) = 229 +/- 20 nM. I tua atu, i whakaatu tata ki te 300-fold te whiriwhiringa mo te 5-LOX i runga i te 12-LOX me te 15-LOX me te kore e whakaatu he mahi ki nga enzymes cyclooxygenase. I tua atu, ka whakakorehia e te PF-4191834 te 5-LOX i roto i nga ruma toto tangata, me te IC(80) = 370 +/- 20 nM. |
| CPD100599 | MK-886 | Ko MK-886, e mohiotia ana ko L 663536, he kaitukino leukotriene. Ka mahia tenei ma te aukati i te 5-lipoxygenase activating protein (FLAP), ka aukati i te 5-lipoxygenase (5-LOX), ka awhina pea ki te rongoa i te atherosclerosis. Ko te MK-886 te aukati i te mahi cyclooxygenase-1 me te whakakore i te whakahiato pereti. Ko te MK-886 e whakaohooho ana i nga huringa o te huringa pūtau me te whakanui ake i te apoptosis i muri i te whakamaaramatanga photodynamic me te hypericin. Ko te MK-886 te whakanui ake i te mate pukupuku mate-a-alpha-induced differentiation and apoptosis. |
| CPD100598 | L-691816 | Ko L 691816 he aukati kaha o te tauhohenga 5-LO i roto i te vitro me te awhe o nga tauira in vivo. |
| CPD100597 | CMI-977 | Ko te CMI-977, e mohiotia ana ko LPD-977 me MLN-977, he aukati 5-lipoxygenase kaha e wawao ana ki te hanga leukotrienes, a kei te whakawhanakehia inaianei mo te maimoatanga o te mate huango mau tonu. Ka aukati te CMI-977 i te ara mumura o te 5-lipoxygenase (5-LO) ki te aukati i te whakatipuranga o nga leukotrienes, e whai waahi nui ana ki te whakaoho i te mate huango. |
| CPD100596 | CJ-13610 | Ko te CJ-13610 he aukati kaha-waha o te 5-lipoxygenase (5-LO) . Ka whakakorehia e CJ-13610 te koiora o te leukotriene B4 me te whakahaere i te whakaaturanga IL-6 mRNA i roto i nga macrophages. He whai hua i roto i nga tauira o mua o te mamae. |
| CPD100595 | BRP-7 | Ko te BRP-7 he 5-LO activating protein (FLAP) aukati. |
