ND-630

Ingoa matū:

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide

Waehere SMILES:

O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O

Waehere InChi:

InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(3 9-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10, 12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1

Kī InChi:

ZZWWXIBKLBMCSCS-FQEVSTJZSA-N

Kupumatua:

ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te ND-630 te aukati i te hACC1 (IC50=2.1±0.2 nM) me te hACC2 (IC50=6.1±0.8 nM). Ka taea te whakahuri me te tino motuhake mo te ACC. Ko te ND-630 he aukati i te mahi ACC ma te taunekeneke i roto i te phosphopeptide-acceptor me te waahi dimerization o te enzyme hei aukati i te dimerization. Ko te ND-630 te aukati i te whakahiato waikawa ngako me te EC50 o 66 nM i roto i nga pūtau HepG2 me te kore e whakarereke i te katoa o te tau pūtau, te kukū pūmua pūtau, me te whakauru o te acetate ki te cholesterol[1].

Whāinga: ACC